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The Black Death has his many countries around the world killing millions. An estimated 100 million at it's height, may be more, in the mid 14th century. The Black Death is commonly thought to be an out break of bubonic plague, although this has been questioned.

The first outbreak in the Britain was between 1348 and 1349, entering the country through the port of Melcombe Regis, now Weymouth, on 25th June 1348. Villagers in the area quickly contracted the disease and people started to die.  Villagers that were unaffected, or could travel, soon moved to other parts of the country to escape.  Although some were immune, they may still have carried fleas.  This cause an epidemic, even a pandemic as at the time the disease was ripe across Europe.  To reduce the risk of infection, some villages errected walls and shut themselves off to the outside world. 

It is estimated that 30% to 50% of the British population died by infection from this disease.  The plauge did re-surface in the mid 17th century.

What if the plauge had not occurred?

So 1348 came and went with no noticable events.  The population carried on as normal.  However, as the population was not decimated by the plauge, the population rises faster than before.  By th 16th century, agriculture is feeling the strain and new inventions such as the seeddrill are invented much earlier than previous.  This kickstarts the industrial revolution one or two hundred years ahead of it time.  London grows out of all proportion and by the modern day even places as far away as REading are considered to be in London with no borders between towns.

What if the plauge had wiped out more?

Consider the plauge lasting for longer or killing more people.  90% of the population are wiped out, leaving a small scattered few.  Many being the only surviours in their villages, they leave to find villages better populated.  Thus many villages are lost.  London being one of the worst hit, is a mere shadow today of what it should be.  The population struggles to regain its foothold, and settlers from other countries soon start to arrive, possibly the French.  Britain is no longer.